Itgb6^tm1Des
Targeted Allele Detail

Summary

• Symbol: Itgb6^tm1Des
• Name: integrin beta 6; targeted mutation 1, Dean Sheppard
• MGI ID: MGI:1926484
• Synonyms: beta6-, Itgb6^-
• Gene: Itgb6 Location: Chr2:60428636-60552987 bp, - strand Genetic Position: Chr2, 34.81 cM, cytoband C3
• Alliance: Itgb6^tm1Des page

Juvenile baldness in Itgb6^tm1Des/Itgb6^tm1Des mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33139
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Insertion of a neomycin gene into a coding exon of the Itgb6 gene. (J:33139)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Itgb6^tm1Des

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb6 Mutation: 32 strains or lines available

References

• Original: J:33139 Huang XZ, et al., Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May;133(4):921-8
• All: 35 reference(s)