Igf1r^tm1Arge
Targeted Allele Detail

Summary

• Symbol: Igf1r^tm1Arge
• Name: insulin-like growth factor I receptor; targeted mutation 1, Argiris Efstratiadis
• MGI ID: MGI:1926486
• Synonyms: Igf1r-, Igf1rⁿ
• Gene: Igf1r Location: Chr7:67602575-67883416 bp, + strand Genetic Position: Chr7, 37.27 cM
• Alliance: Igf1r^tm1Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15108
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of sequences encoding part of exon 3 with a neomycin resistance gene. (J:15108)
• Inheritance: Dominant

Expression

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf1r Mutation: 88 strains or lines available

References

• Original: J:15108 Liu JP, et al., Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 1993 Oct 8;75(1):59-72
• All: 31 reference(s)