Tg(ITGB1)0840Fmw
Transgene Detail

Summary

• Symbol: Tg(ITGB1)0840Fmw
• Name: transgene insertion 0840, Fiona M Watt
• MGI ID: MGI:1926494
• Synonyms: 0840 beta1
• Transgene: Tg(ITGB1)0840Fmw Location: unknown
• Alliance: Tg(ITGB1)0840Fmw page

Transgene origin

• Strain of Origin: (CBA x C57BL/10)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ITGB1)0840Fmw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ITGB1 (3688)

  Itgb1

  (MGI:96610)

• Mutation details: Overexpression of human integrin beta 1 (ITGB1) in the suprabasal layers of the epidermis driven by the human involucrin (IVL) promoter. 42 copies of this gene were inserted, as determined by southern blotting. (J:30249)
• Inheritance: Not Specified

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

See also Tg(ITGB1)0869Fmw and Tg(ITGB1)0870Fmw for variability in transgene copy number using this construct. Severity of described phenotypes correlates to the copy number of the transgenes.

References

• Original: J:30249 Carroll JM, et al., Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell. 1995 Dec 15;83(6):957-68
• All: 4 reference(s)