Chek1^tm1Sje
Targeted Allele Detail

Summary

• Symbol: Chek1^tm1Sje
• Name: checkpoint kinase 1; targeted mutation 1, Stephen J Elledge
• MGI ID: MGI:1926528
• Synonyms: CHK1^-
• Gene: Chek1 Location: Chr9:36619935-36637897 bp, - strand Genetic Position: Chr9, 20.67 cM, cytoband A5.3
• Alliance: Chek1^tm1Sje page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62919
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of 3kb of the gene encoding the translation start site, the "GxGxxG" ATP-binding motif and half of the kinase domain with a neomycin gene. (J:62919)

Tumor Data

List all tumor models in MMHCdb carrying Chek1^tm1Sje

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chek1 Mutation: 41 strains or lines available

References

• Original: J:62919 Liu Q, et al., Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 2000 Jun 15;14(12):1448-59
• All: 3 reference(s)