Lef1^tm1Rug
Targeted Allele Detail

Summary

• Symbol: Lef1^tm1Rug
• Name: lymphoid enhancer binding factor 1; targeted mutation 1, Rudolf Grosschedl
• MGI ID: MGI:1926601
• Synonyms: Lef1-, LEF-1-, Lef1-neo
• Gene: Lef1 Location: Chr3:130904120-131018005 bp, + strand Genetic Position: Chr3, 60.78 cM
• Alliance: Lef1^tm1Rug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18378
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of neomycin gene into exon encoding the DNA-binding HMG domain causing elimination of protein expression. (J:18378)

Expression

In Mice Carrying this Mutation:	45 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lef1 Mutation: 43 strains or lines available

References

• Original: J:18378 van Genderen C, et al., Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 1994 Nov 15;8(22):2691-703
• All: 34 reference(s)