Tg(Notch1)A3Rko
Transgene Detail

Summary

• Symbol: Tg(Notch1)A3Rko
• Name: transgene insertion A3, Raphael Kopan
• MGI ID: MGI:1926625
• Synonyms: MHKA-Notch^deltaE
• Transgene: Tg(Notch1)A3Rko Location: unknown
• Alliance: Tg(Notch1)A3Rko page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Notch1)A3Rko expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Notch1 (MGI:97363)

• Mutation details: Overexpression of a truncated, activated form of Myc-tagged Notch1 in precursor and differentiating cells of the hair cortex, driven by the mouse hair keratin A1 (Krt1) gene. 4 copies of the gene were inserted, as estimated by southern blotting. (J:62217)
• Inheritance: Not Specified

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(Notch1)A3Rko/0	involves: FVB/N

Phenotypes:

Affected Systems	tg1
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normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:62217 Lin MH, et al., Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. Development. 2000 Jun;127(11):2421-32
• All: 1 reference(s)