Tg(Notch1)A5Rko
Transgene Detail

Summary

• Symbol: Tg(Notch1)A5Rko
• Name: transgene insertion A5, Raphael Kopan
• MGI ID: MGI:1926630
• Synonyms: MHKA-Notch^deltaE
• Transgene: Tg(Notch1)A5Rko Location: unknown
• Alliance: Tg(Notch1)A5Rko page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Notch1)A5Rko expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Notch1 (MGI:97363)

• Mutation details: Overexpression of a truncated, activated form of Myc-tagged Notch1 in precursor and differentiating cells of the hair cortex, driven by the mouse hair keratin A1 (Krt1) gene. 6 copies of the gene were inserted, as estimated by southern blotting. (J:62217)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:62217 Lin MH, et al., Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. Development. 2000 Jun;127(11):2421-32
• All: 2 reference(s)