Tg(Notch1)1Anc
Transgene Detail

Summary

• Symbol: Tg(Notch1)1Anc
• Name: transgene insertion 1, Angela M Christiano
• MGI ID: MGI:1926638
• Transgene: Tg(Notch1)1Anc Location: unknown
• Alliance: Tg(Notch1)1Anc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Notch1)1Anc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Notch1 (MGI:97363)

• Mutation details: Overexpression of an epitope tagged Notch1 in the inner root sheath of hair follicles driven by the ivolucrin (Ivl) promoter (species not specified). Beta-galactosidase expression was driven concurrently by the involucrin promoter using an internal ribosomal entry site (IRES). (NOTE: This abstract does not indicate which species of Notch1 or involucrin is being used) (J:65042)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Several transgenic lines were established. This is a representative line.

References

• Original: J:65042 Uyttendaele H, et al., Abstracts for the 61st annual meeting of the society for investigative dermatology (Targeted overexpression of Notch1 in the hair follicle leads to defects in inner root sheath differentiation and dysregulation of hair cycling). J Invest Dermatol. 2000;114:747-888 (754 (Abstr))
• All: 1 reference(s)