Tg(KRT14-PTHLH)7Wmp
Transgene Detail

Summary

• Symbol: Tg(KRT14-PTHLH)7Wmp
• Name: transgene insertion 7, William M Philbrick
• MGI ID: MGI:1926698
• Synonyms: K14-PTHrP, Tg(PTHLH)7Wmp
• Transgene: Tg(KRT14-PTHLH)7Wmp Location: unknown
• Alliance: Tg(KRT14-PTHLH)7Wmp page

Dental phenotype of Pthlh^tm1Hmk/Pthlh^tm1Hmk mice rescued with Tg(Col2a1-PTHLH)2Ecw and Tg(KRT14-PTHLH)7Wmp transgenes

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-PTHLH)7Wmp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTHLH (5744)

  Pthlh

  (MGI:97800)

• Mutation details: Overexpression of human parathyroid hormone-related peptide (PTHLH) in basal epidermis and outer root sheath of hair follicles driven by the human K14 (KRT14) promoter. (J:65403)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic mice derived from an additional founder, designated line 6, was described as having an identical phenotype.

References

• Original: J:65043 Wysolmerski JJ, et al., Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1133-7
• All: 16 reference(s)