Pdgfra^tm2Sor
Targeted Allele Detail

Summary

• Symbol: Pdgfra^tm2Sor
• Name: platelet derived growth factor receptor, alpha polypeptide; targeted mutation 2, Philippe Soriano
• MGI ID: MGI:1926728
• Synonyms: alphaR2-4, alphaR4
• Gene: Pdgfra Location: Chr5:75312953-75358876 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Pdgfra^tm2Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41814
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of intronic sequences encoding the signal peptide, and the first and second immunoglobulin domains with a loxP-flanked neomycin cassette. (J:41814)

Disease models

Expression

In Structures Affected by this Mutation:

32 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfra Mutation: 88 strains or lines available

References

• Original: J:41814 Soriano P, The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development. 1997 JUL;124(14):2691-2700
• All: 10 reference(s)