Xrcc4^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Xrcc4^tm1Fwa
• Name: X-ray repair complementing defective repair in Chinese hamster cells 4; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:1926771
• Synonyms: XRCC4-
• Gene: Xrcc4 Location: Chr13:89997033-90237727 bp, - strand Genetic Position: Chr13, 45.5 cM
• Alliance: Xrcc4^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65218
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of sequence encoding exon 3 of the Xrcc4 gene with a loxP-flanked neomycin cassette. This cassette was then removed by crossing mice with germline-Cre expressing mice to generate this allele containing a deletion of exon 3. Any potential transcript from this allele that spliced from exon 2 to exon 4 or 5 would harbor a frameshift mutation. (J:65218)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Xrcc4^tm1Fwa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xrcc4 Mutation: 26 strains or lines available

References

• Original: J:65218 Gao Y, et al., A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 1998 Dec 23;95(7):891-902
• All: 22 reference(s)