Tg(Tgfb1)1Der
Transgene Detail

Summary

• Symbol: Tg(Tgfb1)1Der
• Name: transgene insertion 1, Dennis R Roop
• MGI ID: MGI:1926811
• Synonyms: HK1.TGF-beta1
• Transgene: Tg(Tgfb1)1Der Location: unknown
• Alliance: Tg(Tgfb1)1Der page

Transgene origin

• Strain of Origin: (ICR x FVB)F1

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tgfb1)1Der expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  pig, domestic	TGFB1 (397078)

• Tg(Tgfb1)1Der expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT1 (3848)

  Krt1	(MGI:96698)

• Mutation details: Overexpression of a constitutively activated form of pig TGF-beta 1 (TGFB1) in epidermis, driven by the human keratin-1 (KRT1) promoter. (J:65046)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:65046 Sellheyer K, et al., Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5237-41
• All: 2 reference(s)