Stat3^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Stat3^tm1Aki
• Name: signal transducer and activator of transcription 3; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:1926814
• Synonyms: Stat3-
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm1Aki page

Histological analysis of wild type and Stat3^tm1Aki/Stat3^tm1Aki embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40106
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced 3.0kb of sequence containing exons 20-22. (J:40106)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 72 strains or lines available

References

• Original: J:40106 Takeda K, et al., Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3801-4
• All: 57 reference(s)