Tg(KRT5-cre)1Tak
Transgene Detail

Summary

• Symbol: Tg(KRT5-cre)1Tak
• Name: transgene insertion 1, Junji Takeda
• MGI ID: MGI:1926815
• Synonyms: K5-Cre, (K5)-Cre, K5Cre, Keratin5Cre, Tg(Cre)1Tak
• Transgene: Tg(KRT5-cre)1Tak Location: unknown
• Alliance: Tg(KRT5-cre)1Tak page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(KRT5-cre)1Tak expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT5 (3852)

  Krt5	(MGI:96702)

• Mutation details: A 14kb fragment of human keratin 5 (KRT5) promoter was used to control the expression of Cre in keratinocytes. A nuclear localization signal was added to the 5' end of the Cre gene. (J:41746)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT5 (human) Summary of all recombinase alleles driven by KRT5. Alliance human KRT5 gene page

Disease models

Expression

In Mice Carrying this Mutation:	22 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT5-cre)1Tak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:41746 Tarutani M, et al., Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7400-5
• All: 137 reference(s)