Pdgfa^tm1Cbet
Targeted Allele Detail

Summary

• Symbol: Pdgfa^tm1Cbet
• Name: platelet derived growth factor, alpha; targeted mutation 1, Christer Betsholtz
• MGI ID: MGI:1926817
• Synonyms: PDGF-A (-)
• Gene: Pdgfa Location: Chr5:138961769-138983125 bp, - strand Genetic Position: Chr5, 77.65 cM
• Alliance: Pdgfa^tm1Cbet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33629
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exon 4 of Pdgfa gene, which encodes the N-terminal half of the mature Pdgfa chain, with a neomycin cassette. (J:33629)

Expression

In Mice Carrying this Mutation:	61 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfa Mutation: 20 strains or lines available

References

• Original: J:33629 Bostrom H, et al., PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell. 1996 Jun 14;85(6):863-73
• All: 17 reference(s)