Phox2b^tm1Jbr
Targeted Allele Detail

Summary

• Symbol: Phox2b^tm1Jbr
• Name: paired-like homeobox 2b; targeted mutation 1, Jean-Francois Brunet
• MGI ID: MGI:1926861
• Synonyms: Phox2b-, Phox2b^LacZ
• Gene: Phox2b Location: Chr5:67251751-67256399 bp, - strand Genetic Position: Chr5, 35.95 cM
• Alliance: Phox2b^tm1Jbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55391
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of a lacZ gene in frame into the second exon, which encodes the homeobox domain. A neomycin resistance cassette follows the lacZ gene. This allele expresses beta-galctosidase under the control of the endogenous promoter elements. (J:55391)

Expression

In Mice Carrying this Mutation:	142 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phox2b Mutation: 25 strains or lines available

References

• Original: J:55391 Pattyn A, et al., The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature. 1999 May 27;399(6734):366-70
• All: 36 reference(s)