Cdkn2a^tm1Cjs
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm1Cjs
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr
• MGI ID: MGI:1926877
• Synonyms: ARF-, p19Arf^-, p19^ARF-, p19^Arf-null
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm1Cjs page

Abnormal retrolental tissue present in the eyes of neonatal Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44427
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exon 1 beta of the Cdkn2a gene, encoding the translation start site for alternative splice transcript p19^ARF, with a neomycin cassette. Note that expression of alternative splice transcript p16^Ink4a, transcribed from exon 1 alpha, is not affected by this mutation. (J:44427)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2a^tm1Cjs

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 67 strains or lines available

References

• Original: J:44427 Kamijo T, et al., Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell. 1997 Nov 28;91(5):649-59
• All: 166 reference(s)