Crebbp^tm1Dli
Targeted Allele Detail

Summary

• Symbol: Crebbp^tm1Dli
• Name: CREB binding protein; targeted mutation 1, David Livingston
• MGI ID: MGI:1926888
• Synonyms: CBP^-
• Gene: Crebbp Location: Chr16:3899198-4031864 bp, - strand Genetic Position: Chr16, 2.4 cM
• Alliance: Crebbp^tm1Dli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60630
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of two exons encoding the CH1 domain of the Crebbp gene with a neomycin cassette. (J:60630)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Crebbp^tm1Dli

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crebbp Mutation: 100 strains or lines available

References

• Original: J:60630 Kung AL, et al., Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 2000 Feb 1;14(3):272-7
• All: 11 reference(s)