Ring1^tm1Mvi
Targeted Allele Detail

Summary

• Symbol: Ring1^tm1Mvi
• Name: ring finger protein 1; targeted mutation 1, Miguel Vidal
• MGI ID: MGI:1926913
• Synonyms: Ring1A^-
• Gene: Ring1 Location: Chr17:34239766-34243654 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: Ring1^tm1Mvi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65300
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Deletion of the first six exons, including the sequences encoding the translation initiation start site, the RING finger domain, the homology domain 2 and part of the homology domain 3. These sequences were replaced with an HPRT minigene. (J:65300)

Expression

In Mice Carrying this Mutation:	6 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ring1 Mutation: 17 strains or lines available

References

• Original: J:65300 del Mar Lorente M, et al., Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice. Development. 2000 Dec;127(23):5093-100
• All: 41 reference(s)