Tg(Krt2-6a)3Der
Transgene Detail

Summary

• Symbol: Tg(Krt2-6a)3Der
• Name: transgene insertion 3, Dennis R Roop
• MGI ID: MGI:1926924
• Synonyms: MK6adelta2B-P
• Transgene: Tg(Krt2-6a)3Der Location: unknown
• Alliance: Tg(Krt2-6a)3Der page

Transgene origin

• Strain of Origin: FVB x ICR

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Krt2-6a)3Der expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Krt6a (MGI:1100845)

• Mutation details: Overexpression of a mutated form of the mouse Mk6a (Krt2-6a) gene in the interfollicular epidemis driven by the mouse MK6a (Krt2-6a) promoter. The C- terminal 2B, H2,V2 and E2 region of the gene is deleted and replaced by the substance P epitope tag. (J:58389)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

One line established.

Phenotypes: Neonates exhibited severe blistering of the epidermis in heterozygotes. Heterozygous animals surviving to adult developed early onset alopecia at 3 weeks. In addition, keratotic lesions appeared at 2-4 weeks. Hyperplasia and hyperkeratosis of the epidermis. Homozygous animals did not survive longer than one week.

References

• Original: J:58389 Wojcik SM, et al., Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle. Differentiation. 1999 Oct;65(2):97-112
• All: 1 reference(s)