Pax5^tm1Mbu
Targeted Allele Detail

Summary

• Symbol: Pax5^tm1Mbu
• Name: paired box 5; targeted mutation 1, Meinrad Busslinger
• MGI ID: MGI:1926938
• Synonyms: Pax5^-, Pax5-lacZ, Pax5^lacZ
• Gene: Pax5 Location: Chr4:44524757-44710487 bp, - strand Genetic Position: Chr4, 23.55 cM
• Alliance: Pax5^tm1Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21935
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Disruption of the Pax5 gene by an in-frame fusion of the 5'genomic sequences of Pax5 (at codon 21 in exon 2) to a LacZ reporter gene containing a nuclear localization signal. (J:21935)

Expression

In Mice Carrying this Mutation:	67 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pax5^tm1Mbu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax5 Mutation: 37 strains or lines available

References

• Original: J:21935 Urbanek P, et al., Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP [see comments]. Cell. 1994 Dec 2;79(5):901-12
• All: 53 reference(s)