Nkx3-1^tm1Mms
Targeted Allele Detail

Summary

• Symbol: Nkx3-1^tm1Mms
• Name: NK3 homeobox 1; targeted mutation 1, Michael M Shen
• MGI ID: MGI:1926960
• Synonyms: Nkx3.1^-
• Gene: Nkx3-1 Location: Chr14:69428141-69432107 bp, + strand Genetic Position: Chr14, 36.02 cM
• Alliance: Nkx3-1^tm1Mms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54465
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of sequences encoding the homeodomain and carboxy-terminus of the gene with a PGK-neomycin cassette. (J:54465)

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nkx3-1^tm1Mms

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Nkx3-1 Mutation: 38 strains or lines available

References

• Original: J:54465 Bhatia-Gaur R, et al., Roles for Nkx3.1 in prostate development and cancer. Genes Dev. 1999 Apr 15;13(8):966-77
• All: 28 reference(s)