B2m^tm1Jae
Targeted Allele Detail

Summary

• Symbol: B2m^tm1Jae
• Name: beta-2 microglobulin; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:1927183
• Synonyms: B2M-, beta2M-, beta2m^null, MHC classI^-
• Gene: B2m Location: Chr2:121978168-121983563 bp, + strand Genetic Position: Chr2, 60.55 cM, cytoband F1-F3
• Alliance: B2m^tm1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65613
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into the second exon. (J:65613, J:80910)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 8 strains available Cell Lines: 0 lines available
• Carrying any B2m Mutation: 122 strains or lines available

References

• Original: J:65613 Zijlstra M, et al., Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature. 1989 Nov 23;342(6248):435-8
• All: 222 reference(s)