Nrgn^tm1Kph
Targeted Allele Detail

Summary

• Symbol: Nrgn^tm1Kph
• Name: neurogranin; targeted mutation 1, Kuo-Ping Huang
• MGI ID: MGI:1927195
• Synonyms: Ng^-
• Gene: Nrgn Location: Chr9:37455789-37464041 bp, - strand Genetic Position: Chr9, 20.78 cM
• Alliance: Nrgn^tm1Kph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65166
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of a LacZ gene in frame into the first coding exon, followed by a neomycin cassette. No NRGN immunoreactivity was detected in brain sections derived from homozygous mutant mice. X-gal staining in homozygous mutant mice corresponded with the NRGN positive staining in wild-type mice. (J:65166)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrgn Mutation: 8 strains or lines available

References

• Original: J:65166 Pak JH, et al., Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: A study with knockout mice. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11232-7
• All: 12 reference(s)