Nkx2-5^tm1Wehi
Targeted Allele Detail

Summary

• Symbol: Nkx2-5^tm1Wehi
• Name: NK2 homeobox 5; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:1927227
• Synonyms: Nkx2-5^HDneo
• Gene: Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
• Alliance: Nkx2-5^tm1Wehi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27443
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A replacement-type targeting vector was constructed in which sequences coding for helix 3 of the homeodomain were disrupted by insertion of a neoR gene cassette. (J:27443)

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-5 Mutation: 21 strains or lines available

References

• Original: J:27443 Lyons I, et al., Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 1995 Jul 1;9(13):1654-66
• All: 12 reference(s)