Cd74^tm1Eae
Targeted Allele Detail

Summary

• Symbol: Cd74^tm1Eae
• Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 1, Eileen A Elliott
• MGI ID: MGI:1927544
• Synonyms: CD74-KO, delta Ii, Ii-
• Gene: Cd74 Location: Chr18:60936921-60945724 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Cd74^tm1Eae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65917
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance cassette. Absence of protein expression was confirmed by immunohistochemistry on LPS-treated splenocytes. (J:65917)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd74 Mutation: 36 strains or lines available

References

• Original: J:65917 Elliott EA, et al., The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J Exp Med. 1994 Feb 1;179(2):681-94
• All: 34 reference(s)