Ntn1^Gt(ST629)Byg
Gene trapped Allele Detail

Summary

• Symbol: Ntn1^Gt(ST629)Byg
• Name: netrin 1; gene trap ST629, BayGenomics
• MGI ID: MGI:1927548
• Synonyms: Netrin-1^-, Netrin-1^betageo, Netrin-1^LacZ, ntn1 -, Ntn1^Gt, Ntn1^{Gt(pGT1.8TM)629Ecs}, Ntn1^{Gt(pGT1.8TM)629Wcs}
• Gene: Ntn1 Location: Chr11:68100190-68277652 bp, - strand Genetic Position: Chr11, 41.45 cM, cytoband B3
• Alliance: Ntn1^Gt(ST629)Byg page

Mutation origin

• Mutant Cell Line: ST629
• Germline Transmission: Earliest citation of germline transmission: J:37125
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1.8TM
• Mutation details: The integration of gene trap vector pGT1.8TM occurred in an intron of the netrin 1 gene. The mutant allele is likely to be hypomorphic rather than null, since some of the wild-type transcripts are present, presumably by splicing over the inserted sequences. (J:37125)
• Inheritance: Recessive
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  ST629	CC144759 ; (MGI Seq Detail)	5' RACE	Chr11:68168248-68168399 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  26 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	152 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntn1 Mutation: 107 strains or lines available

References

• Original: J:37125 Serafini T, et al., Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 1996 Dec 13;87(6):1001-14
• All: 81 reference(s)