Myf6^tm1Thbr
Targeted Allele Detail

Summary

• Symbol: Myf6^tm1Thbr
• Name: myogenic factor 6; targeted mutation 1, Thomas Braun
• MGI ID: MGI:1927607
• Synonyms: Myf-6, Myf-6^m1
• Gene: Myf6 Location: Chr10:107328709-107330584 bp, - strand Genetic Position: Chr10, 55.96 cM
• Alliance: Myf6^tm1Thbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24360
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette was inserted into exon 1 of the gene, removing nucleotides -5 to +207. This disruption was shown to eliminate Myf5 expression as well. (J:24360)

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myf6 Mutation: 19 strains or lines available

Notes

Homozygotes show absence of Myf5 expression and resemble most of the phenotypes seen in Myf5 null mice (J:24360). Analysis has shown that most likely, Myf6 regulates Myf5 expression by a cis-acting mechanism and the skeletal abnormalities result from the absence of Myf5 rather than Myf6 (J:31636, J:42453).

References

• Original: J:24360 Braun T, et al., Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development. EMBO J. 1995 Mar 15;14(6):1176-86
• All: 4 reference(s)