Myog^tm1Yin
Targeted Allele Detail

Summary

• Symbol: Myog^tm1Yin
• Name: myogenin; targeted mutation 1, Yo-ichi Nabeshima
• MGI ID: MGI:1927620
• Synonyms: MyoG^mt-1
• Gene: Myog Location: Chr1:134217742-134220286 bp, + strand Genetic Position: Chr1, 58.18 cM
• Alliance: Myog^tm1Yin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:14059
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 1 of the Myog locus upstream of the basic-helix-loop-helix encoding domain. This mutation disrupted the reading frame of the protein. (J:14059)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myog Mutation: 14 strains or lines available

References

• Original: J:14059 Nabeshima Y, et al., Myogenin gene disruption results in perinatal lethality because of severe muscle defect [see comments]. Nature. 1993 Aug 5;364(6437):532-5
• All: 2 reference(s)