Hus1^tm1Led
Targeted Allele Detail

Summary

• Symbol: Hus1^tm1Led
• Name: HUS1 checkpoint clamp component; targeted mutation 1, Philip Leder
• MGI ID: MGI:1927769
• Synonyms: Hus1^-, Hus1^delta1n
• Gene: Hus1 Location: Chr11:8943137-8961191 bp, - strand Genetic Position: Chr11, 5.74 cM
• Alliance: Hus1^tm1Led page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63869
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1kb of the gene, including exon 1 and the translation initiation codon. (J:63869)

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hus1 Mutation: 20 strains or lines available

References

• Original: J:63869 Weiss RS, et al., Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress. Genes Dev. 2000 Aug 1;14(15):1886-98
• All: 9 reference(s)