Sell^tm1Tft
Targeted Allele Detail

Summary

• Symbol: Sell^tm1Tft
• Name: selectin, lymphocyte; targeted mutation 1, Thomas F Tedder
• MGI ID: MGI:1927795
• Synonyms: CD62L^-, CD62L KO, L^-, L-selectin^-, selectin^-
• Gene: Sell Location: Chr1:163889556-163908354 bp, + strand Genetic Position: Chr1, 71.37 cM
• Alliance: Sell^tm1Tft page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25005
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance gene replaced the majority of the exon encoding the L-selectin domain. (J:25005)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sell Mutation: 42 strains or lines available

References

• Original: J:25005 Arbones ML, et al., Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity. 1994 Jul;1(4):247-60
• All: 64 reference(s)