Trp53^tm1Wahl
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Wahl
• Name: transformation related protein 53; targeted mutation 1, Geoffrey M Wahl
• MGI ID: MGI:1927802
• Synonyms: Trp53^QS
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Wahl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64367
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Leucine codon 25 (TTA) and tryptophan codon 26 (TGG) were changed to glutamine (CAA) and serine (TCG) (p.L25Q, p.W26S). This mutation is similar to a known human mutation. The allele also contains a spontaneous or strain specific p.A135V mutation (compared to C57BL/6). (J:64367)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1Wahl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 239 strains or lines available

References

• Original: J:64367 Jimenez GS, et al., A transactivation-deficient mouse model provides insights into trp53 regulation and function (Erratum: Nat Genet 2005;37(2):205). Nat Genet. 2000 Sep;26(1):37-43
• All: 9 reference(s)