Fgf10^tm1Wss
Targeted Allele Detail

Summary

• Symbol: Fgf10^tm1Wss
• Name: fibroblast growth factor 10; targeted mutation 1, W Scott Simonet
• MGI ID: MGI:1927833
• Synonyms: Fgf-10^-, Fgf10^-, fgf10^neo
• Gene: Fgf10 Location: Chr13:118851199-118928651 bp, + strand Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
• Alliance: Fgf10^tm1Wss page

Palatal abnormalities in Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn and Fgf10^tm1Wss/Fgf10^tm1Wss mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50768
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of part of exon 1 containing the transcription start site with a PGK-neomycin cassette (J:50768)

Disease models

Expression

In Mice Carrying this Mutation:	52124 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	39 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf10 Mutation: 33 strains or lines available

References

• Original: J:50768 Min H, et al., Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 1998 Oct 15;12(20):3156-61
• All: 47 reference(s)