Hoxd10^tm1Emca
Targeted Allele Detail

Summary

• Symbol: Hoxd10^tm1Emca
• Name: homeobox D10; targeted mutation 1, Ellen M Carpenter
• MGI ID: MGI:1927871
• Gene: Hoxd10 Location: Chr2:74522268-74525449 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Hoxd10^tm1Emca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59070
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: An EcoRI linker was inserted into exon 2. This insertion is predicted to cause a frameshift altering the identity of downstream amino acids and introducing a premature stop codon 19 amino acids after the insertion. (J:59070)
• Inheritance: Not Specified

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Hoxd9^tm1Emca/Hoxd9^tm1Emca Hoxd10^tm1Emca/Hoxd10^tm1Emca	involves: 129S7/SvEvBrd * C57BL/6

Phenotypes:

Affected Systems	cx1
show or hide all annotated terms Sex:
behavior/neurological	√	√
abnormal stationary movement	√	√
abnormal locomotor behavior	√	√
abnormal gait	√	√
short stride length	√	√
decreased vertical activity	√	√
decreased locomotor activity	√	√
cellular	√	√
abnormal axon fasciculation	√	√
limbs/digits/tail	√	√
abnormal forelimb morphology	√	√
abnormal humerus morphology	√	√
abnormal deltoid tuberosity morphology	√	√
abnormal hindlimb morphology	√	√
abnormal patella morphology	√	√
abnormal sesamoid bone of gastrocnemius morphology	√	√
mortality/aging	√	√
pregnancy-related premature death	√	√
muscle	√	√
abnormal skeletal muscle morphology	√	√
abnormal tendon morphology	√	√
nervous system	√	√
abnormal axon fasciculation	√	√
abnormal spinal nerve morphology	√	√
abnormal sciatic nerve morphology	√	√
renal/urinary system	√	√
small kidney	√	√
reproductive system	N	√
reproductive system phenotype	N	N
male infertility		√
skeleton	√	√
abnormal humerus morphology	√	√
abnormal deltoid tuberosity morphology	√	√
abnormal patella morphology	√	√
abnormal sesamoid bone of gastrocnemius morphology	√	√
abnormal tendon morphology	√	√
abnormal lumbar vertebrae morphology	√	√
abnormal sacral vertebrae morphology	√	√
sacral vertebral transformation	√	√
abnormal joint morphology	√	√
sacral vertebral fusion	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd10 Mutation: 15 strains or lines available

References

• Original: J:59070 de la Cruz CC, et al., Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. Dev Biol. 1999 Dec 15;216(2):595-610
• All: 2 reference(s)