Spi1^tm1Ram
Targeted Allele Detail

Summary

• Symbol: Spi1^tm1Ram
• Name: Spi-1 proto-oncogene; targeted mutation 1, Richard A Maki
• MGI ID: MGI:1927876
• Synonyms: PU.1 (-)
• Gene: Spi1 Location: Chr2:90912750-90946104 bp, + strand Genetic Position: Chr2, 50.44 cM, cytoband E3
• Alliance: Spi1^tm1Ram page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36473
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Insertion of a neomycin gene into exon 5, which encodes the DNA binding domain. (J:36473)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spi1 Mutation: 28 strains or lines available

References

• Original: J:36473 McKercher SR, et al., Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996 Oct 15;15(20):5647-58
• All: 23 reference(s)