Grin1^tm1Stl
Targeted Allele Detail

Summary

• Symbol: Grin1^tm1Stl
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, Susumu Tonegawa
• MGI ID: MGI:1928270
• Synonyms: NMDAR1-, NR1-
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17384
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 2.4kb genomic fragment containing exons encoding four transmembrane domains. (J:17384)

Disease models

Expression

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 66 strains or lines available

References

• Original: J:17384 Li Y, et al., Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Cell. 1994 Feb 11;76(3):427-37
• All: 21 reference(s)