Grin1^tm2Stl
Targeted Allele Detail

Summary

• Symbol: Grin1^tm2Stl
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 2, Susumu Tonegawa
• MGI ID: MGI:1928279
• Synonyms: Flox-B, floxed-NR1, fNR1, Grin1^fx, NR1^flox
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm2Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37457
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Insertion of loxP sites flanking the entire transmembrane region (exons 11-21 through the 3' end of the gene). (J:37457)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 67 strains or lines available

References

• Original: J:37457 Tsien JZ, et al., The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell. 1996 Dec 27;87(7):1327-38
• All: 161 reference(s)