Emx1^tm1(cre)Ito
Targeted Allele Detail

Summary

• Symbol: Emx1^tm1(cre)Ito
• Name: empty spiracles homeobox 1; targeted mutation 1, Shigeyoshi Itohara
• MGI ID: MGI:1928281
• Synonyms: (Emx1)Cre, Emx1-Cre, Emx1^Cre, Emx1Cre, Emx1^tm1(cre)Rik
• Gene: Emx1 Location: Chr6:85164913-85181445 bp, + strand Genetic Position: Chr6, 37.21 cM
• Alliance: Emx1^tm1(cre)Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64064
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Emx1^tm1(cre)Ito expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Emx1 (MGI:95387)

• Mutation details: A cDNA encoding cre recombinase with an N-terminal nuclear localization signal (nls) was inserted immediately before the translation initiation codon in the gene. Under the control of this promoter, Cre activity is detected by embryonic day 12.5; Cre mediated recombination was observed in dorsal telencephalon, neocortex, hippocampus, and olfactory bulb. An Frt flanked Neo cassette was retained in this allele (J:64064)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Emx1 (mouse) Summary of all recombinase alleles driven by Emx1. Comparative matrix view of recombinase activities Alliance mouse Emx1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

18 assay results 9 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Emx1 Mutation: 34 strains or lines available

References

• Original: J:64064 Iwasato T, et al., Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature. 2000 Aug 17;406(6797):726-31
• All: 103 reference(s)