Grin1tm1Blt
Targeted Allele Detail
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Symbol: |
Grin1tm1Blt |
Name: |
glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, Horst Bluethmann |
MGI ID: |
MGI:1928283 |
Synonyms: |
Grin1D481N, Grin1tm1Jnck |
Gene: |
Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
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Alliance: |
Grin1tm1Blt page
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Germline Transmission: |
Earliest citation of germline transmission:
J:62289
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Point mutations were introduced by homologous recombination which altered the sequence corresponding to codon 481 from aspartic acid to asparagine. A loxP flanked neomycin/thymidine kinase cassette in intron 10 was removed by transient Cre recombinase expression, leaving one loxP site in the intron.
(J:62289)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Grin1 Mutation: |
66 strains or lines available
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Original: |
J:62289 Kew JN, et al., Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site. J Neurosci. 2000 Jun 1;20(11):4037-49 |
All: |
5 reference(s) |
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