Grin1^tm2Blt
Targeted Allele Detail

Summary

• Symbol: Grin1^tm2Blt
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 2, Horst Bluethmann
• MGI ID: MGI:1928284
• Synonyms: Grin1^K483Q, Grin1^tm2Jnck
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm2Blt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62289
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Point mutations were introduced by homologous recombination which altered the sequence corresponding to codon 483 from lysine to glutamine. A loxP flanked neomycin/thymidine kinase cassette in intron 10 was removed by transient Cre recombinase expression, leaving one loxP site in the intron. (J:62289)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 67 strains or lines available

References

• Original: J:62289 Kew JN, et al., Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site. J Neurosci. 2000 Jun 1;20(11):4037-49
• All: 3 reference(s)