Grin2a^tm1Mim
Targeted Allele Detail

Summary

• Symbol: Grin2a^tm1Mim
• Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1, Masayoshi Mishina
• MGI ID: MGI:1928285
• Synonyms: GluRepsilon1, NR2A-, NR2AKO
• Gene: Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
• Alliance: Grin2a^tm1Mim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22295
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Disruption of the exon encoding the M2 and M3 transmembrane regions by insertion of a PGK-neomycin cassette into an Xcm1 site withing the coding region. (J:22295)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2a Mutation: 66 strains or lines available

References

• Original: J:22295 Sakimura K, et al., Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature. 1995 Jan 12;373(6510):151-5
• All: 75 reference(s)