Grin2a^tm1Rsp
Targeted Allele Detail

Summary

• Symbol: Grin2a^tm1Rsp
• Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1, Rolf Sprengel
• MGI ID: MGI:1928287
• Synonyms: NR2A^deltaC
• Gene: Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
• Alliance: Grin2a^tm1Rsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45446
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Expression of a receptor lacking the intracellular C-terminal domain by insertion of a PGK-neomycin cassette 3' to the M4 transmembrane coding region, with translation stop codons in three frames. (J:45446)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2a Mutation: 66 strains or lines available

References

• Original: J:45446 Sprengel R, et al., Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell. 1998 Jan 23;92(2):279-89
• All: 11 reference(s)