Grin2b^tm1Mim
Targeted Allele Detail

Summary

• Symbol: Grin2b^tm1Mim
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1, Masayoshi Mishina
• MGI ID: MGI:1928295
• Synonyms: NMDA epsilon2 -
• Gene: Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
• Alliance: Grin2b^tm1Mim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31622
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Disruption by insertion of a neomycin cassette into the exon encoding the translation initiation site. (J:31622)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2b Mutation: 99 strains or lines available

References

• Original: J:31622 Kutsuwada T, et al., Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron. 1996 Feb;16(2):333-44
• All: 21 reference(s)