Nrg1^tm2Cbm
Targeted Allele Detail

Summary

• Symbol: Nrg1^tm2Cbm
• Name: neuregulin 1; targeted mutation 2, Carmen Birchmeier
• MGI ID: MGI:1928490
• Synonyms: neuregulin^{deltaEGF-lacZ}, neuregulin-lacZ
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^tm2Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29971
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 is fused to a lacZ gene. Coding sequences downstream of the fusion point, including the N-terminal half of the EGF domain, are deleted. (J:29971)

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 54 strains or lines available

References

• Original: J:29971 Meyer D, et al., Multiple essential functions of neuregulin in development [see comments] [published erratum appears in Nature 1995 Dec 14;378(6558):753]. Nature. 1995 Nov 23;378(6555):386-90
• All: 9 reference(s)