Nrg1^tm1Leth
Targeted Allele Detail

Summary

• Symbol: Nrg1^tm1Leth
• Name: neuregulin 1; targeted mutation 1, Lars E Theill
• MGI ID: MGI:1928491
• Synonyms: neuregulin^Ig, Nrg -
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^tm1Leth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33038
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Part of exon 3, encoding the Ig domain, was replaced with a PGK-neomycin cassette (J:33038)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 54 strains or lines available

References

• Original: J:33038 Kramer R, et al., Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4833-8
• All: 6 reference(s)