Grin2a^tm1Nak
Targeted Allele Detail

Summary

• Symbol: Grin2a^tm1Nak
• Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1, Shigetada Nakanishi
• MGI ID: MGI:1928506
• Synonyms: NR2A -, NR2A KO
• Gene: Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
• Alliance: Grin2a^tm1Nak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66455
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region spanning the second transmembrane domain was deleted and replaced with a neomycin cassette. (J:66455)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Grin2a Mutation: 66 strains or lines available

References

• Original: J:66455 Kadotani H, et al., Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci. 1996 Dec 15;16(24):7859-67
• All: 16 reference(s)