Nkx3-1^tm1Siz
Targeted Allele Detail

Summary

• Symbol: Nkx3-1^tm1Siz
• Name: NK3 homeobox 1; targeted mutation 1, Seigo Izumo
• MGI ID: MGI:1928655
• Synonyms: Nkx3.1 -
• Gene: Nkx3-1 Location: Chr14:69428141-69432107 bp, + strand Genetic Position: Chr14, 36.02 cM
• Alliance: Nkx3-1^tm1Siz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64981
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, encoding the homeodomain and NK-2 specific domain were deleted and replaced by a neomycin cassette. (J:64981)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx3-1 Mutation: 38 strains or lines available

References

• Original: J:64981 Tanaka M, et al., Nkx3.1, a murine homolog of drosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands. Dev Dyn. 2000 Oct;219(2):248-60
• All: 1 reference(s)