Crebbp^{Gt(U-San)112Imeg}
Gene trapped Allele Detail

Summary

• Symbol: Crebbp^{Gt(U-San)112Imeg}
• Name: CREB binding protein; gene trap 112, Institute of Molecular Embryology and Genetics
• MGI ID: MGI:1928775
• Synonyms: CBP^+/-
• Gene: Crebbp Location: Chr16:3899198-4031864 bp, - strand Genetic Position: Chr16, 2.4 cM
• Alliance: Crebbp^{Gt(U-San)112Imeg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53370
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Insertion of the gene trap vector pU-San into an intron of the Crebbp gene located between the exons containing nucleotides 3064-3253 and 3254-3373. Mice carrying this allele express a 121 kd truncated form of the Crebbp protein. (J:53370)

Disease models

Expression

In Structures Affected by this Mutation:

19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crebbp Mutation: 100 strains or lines available

References

• Original: J:53370 Oike Y, et al., Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. Hum Mol Genet. 1999 Mar;8(3):387-96
• All: 4 reference(s)