Chek1^tm1Mkt
Targeted Allele Detail

Summary

• Symbol: Chek1^tm1Mkt
• Name: checkpoint kinase 1; targeted mutation 1, Makoto Nakanishi
• MGI ID: MGI:1928818
• Synonyms: Chk1^-
• Gene: Chek1 Location: Chr9:36619935-36637897 bp, - strand Genetic Position: Chr9, 20.67 cM, cytoband A5.3
• Alliance: Chek1^tm1Mkt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62918
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of a 2.5kb region containing exons 1 and 2 with a neomycin cassette. The translation initiation site and the sequences encoding the ATP-binding region of the kinase are deleted. (J:62918)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Chek1^tm1Mkt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chek1 Mutation: 41 strains or lines available

References

• Original: J:62918 Takai H, et al., Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev. 2000 Jun 15;14(12):1439-47
• All: 4 reference(s)