Nrg1^tm1Gne
Targeted Allele Detail

Summary

• Symbol: Nrg1^tm1Gne
• Name: neuregulin 1; targeted mutation 1, Genentech
• MGI ID: MGI:1928825
• Synonyms: heregulin^-, NRG1(deltaEGF)
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^tm1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45302
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the exon encoding the N-terminal half of the EGF domain with a neomycin cassette. This null mutation results in disruption of all splice forms of Nrg1. (J:45302)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 54 strains or lines available

References

• Original: J:45302 Erickson SL, et al., ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development. 1997 Dec;124(24):4999-5011
• All: 5 reference(s)